Open access
Nov 2026
Alterations in the Immune-Fibrotic Axis Are Spatially Localized in the Aging Heart.
The immune-fibrotic axis functions as a vicious feedback loop where age-related chronic, low-grade systemic inflammation (inflammaging) drives maladaptive tissue repair and fibrosis, while senescent fibrotic cells in turn amplify systemic inflammation. In the aging heart, immune dysregulation and fibroblast activation...
Aleksandra Aljakna Khan, A. Sintou, Yue Zhao et al.
· Aging Cell · 0 citations