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Author

A. Soloperto

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Open access Sep 2026

Defective EV-mediated transport of SHH alters neural fate specification in EPM1 epilepsy

The results demonstrate that EPM1 COs display increased electrophysiological activity and disrupted excitatory/inhibitory (E/I) balance, and identify the CSTB-SHH-EV axis as a potential therapeutic target for mitigating the E/I imbalance associated with EPM1.

Andrea Forero, V. Pravata, Fabrizia Pipicelli et al. · 0 citations

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