Open access
Oct 2026
Thrombin reshapes α-synuclein biochemical properties by N-terminal truncation
Proteolytic processing of α-Synuclein (Syn) contributes to the molecular diversity and toxicity of its aggregates in Parkinson’s disease, yet the proteases responsible for disease-relevant truncations remain incompletely defined. Here, we show that thrombin, a serine protease associated with inflammatory conditions,...
Philipp Trolese, Benedetta Fongaro, Alberto Benetollo et al.
· Nature Communications · 0 citations