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Author

A. Spinazzola

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2 papers indexed here

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Review Oct 2026

Immune checkpoint inhibitors in platinum-resistant ovarian cancer: Clinical disappointments, biological lessons, and the reopening of therapeutic opportunities.

Immune checkpoint inhibitors (ICIs) have transformed the treatment landscape of several malignancies; however, their efficacy in platinum-resistant ovarian cancer (PROC) remains limited. The immunosuppressive tumor microenvironment (TME) in ovarian cancer constitutes a major barrier to effective antitumor immunity, pro...

E. Giudice, A. Spinazzola, C. Floudas et al. · 0 citations
Open access Sep 2026

Early termination of clinical trials enrolling patients with breast cancer: Reasons, determinants, and temporal patterns

Background The occurrence of clinical trial termination before planned completion (or “early termination” [ET]) remains poorly characterized in the breast cancer field. This study investigates the reasons, determinants, and temporal patterns of ET in breast cancer trials. Methods We conducted a cross-sectional study us...

G. M. Iannantuono, G. Daniele, Luca Mastrantoni et al. · 0 citations

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