Unlocking G4 DNA affinity through aromatic side chains: a comparative study of nickel(II), copper(II), and zinc(II) salnaphen derivatives.
Three nickel(II), copper(II), and zinc(II) salnaphen complexes, bearing structurally related charged side chains, were designed to elucidate the role of substituent size and shape in determining their binding strength and affinity for G-quadruplex (G4) DNA structures. Solution DNA-binding studies revealed that aromatic...