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A. Spottke

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Open access Oct 2026

Amyloid, p‐tau, neurofilament light, and α‐synuclein cerebrospinal fluid biomarkers across Alzheimer's disease, dementia with Lewy bodies, and Parkinson's disease

Abstract INTRODUCTION Mounting evidence suggests overlapping pathology across Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and Parkinson's disease (PD), yet its extent and clinical implications remain unclear. METHODS Cerebrospinal fluid (CSF) amyloid beta (Aβ)42/40, phosphorylated tau 181 (p‐tau181), neu...

Marianna Rizzo, C. Teunissen, H. Zetterberg et al. · 0 citations
Open access Sep 2026

Interaction- and asymmetry-aware facial blendshape analysis for objective quantification of Parkinsonian hypomimia

Reduced facial expressivity (hypomimia) is an early motor feature of Parkinson’s disease (PD), yet its assessment still relies on subjective, coarse-grained clinical scales. Using ExpressionTracker, a consumer-grade application built on Apple’s ARKit framework, we derived 261 facial expression features during standardi...

B. Koyak, Timo Menzel, M. Rodemann et al. · 0 citations
Open access Jul 2026

Disruption of temporo-parietal network in Alzheimer’s disease and its association with memory impairment

Findings indicate that temporo-parietal connectivity is associated with both AD molecular pathology and, for a subset of connections, with memory performance, which may provide a link between synaptic pathology and cognitive outcomes.

Yanin Suksangkharn, B. Schott, P. Zeidman et al. · 0 citations
Open access Jul 2026

Automated quantification of white matter hyperintensity confluence: A measure of spatial organisation beyond volume and visual rating scales

WMH confluence is introduced as a reproducible, automated, and fine-grained measure of lesion spatial organisation that provides complementary information about morphological WMH severity beyond volume and is an alternative to visual rating scales.

Tatjana Schmidt, Robert Salzmann, M. Montagnese et al. · 0 citations

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