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Author

A. Spyropoulos

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Review Sep 2026

Perioperative Management of Patients on Factor XI or Factor XIa Inhibitors.

Periprocedural data from completed Phase 2 clinical trials demonstrate that for primary venous thromboprophylaxis of patients undergoing major orthopedic surgery who are at risk of major bleeding, strategies to inhibit FXI result in a lower risk of venous thromboembolism and lower clinically relevant bleeding compared...

A. Spyropoulos, James D. Douketis · 1 citation
Review Open access Sep 2026

Factor XI and XIa Inhibitors: A State-of-the-Art Review Across Clinical Indications

A pattern emerges, where FXI/FXIa inhibition offers a favorable safety profile across multiple settings and high-risk subgroups, yet clear efficacy has so far been established only in secondary prevention of noncardioembolic ischemic stroke over existing antiplatelet strategies.

Ermioni Oikonomou, Mark Goldin, A. Spyropoulos · 0 citations

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