AIMS
This study investigates whether the melatonin (MLT) system modulates the behavioral, neurophysiological and neurochemical effects of fecal microbiota transplantation (FMT) from individuals with schizophrenia (SCZ), highlighting the role of the tryptophan (Trp) to MLT and kynurenine (Kyn) pathways.
MATERIALS AND...
B. Barzon, A. Shkodra, M. D'Incalci et al.· Life Science· 0 citations
BACKGROUND
Impaired cognitive functioning is a severe symptom in major depressive disorder (MDD). Recent evidence suggests it may be a central characteristic in its treatment resistant form (TRD), potentially constituting a clinical marker for treatment resistance and a target amenable to intervention. To date, cogniti...
V. T. Wahner, T. Lange, Inga Stonner et al.· Journal of Affective Disorde...· 0 citations
Investigating the interplay between Trp metabolism, inflammation, and gut microbiota in modulating cognitive and metabolic phenotypes in schizophrenia suggests that dysregulated Trp metabolism acts as a translational bridge connecting genetic background, metabolic status, and microbiota-derived signals to SCZ pathophys...
B. Barzon, A. Shkodra, S. Nasini et al.· International Journal of Neu...· 0 citations
Abstract Background Major depressive disorder (MDD) is the most common mental disorder and is associated with substantial functional impairment, socioeconomic costs and reduced quality of life. One third of patients presents treatment-resistant depression (TRD), a major clinical challenge that highly contributes to the...
C. Pisanu, Y. Xiong, D. Congiu et al.· International Journal of Neu...· 0 citations
Understanding of the genetic architecture of AD in the context of its main genetic driver is improved, and APOE-stratified insights may help understand and overcome side effects, inform clinical trial enrollment strategies, and create the scientific basis for targeted, mechanism-driven therapies in neurodegenerative di...
J. Thomassen, H. Leonard, Brittany Ulms et al.· Nature Genetics· 0 citations
This study suggests that BD patients present significant differences in gene expression patterns compared to healthy controls, and pathway analyses suggest that protein misfolding and endoplasmic reticulum alterations could be implicated in the pathophysiology of BD, while response to lithium might be related to modula...
A. Squassina, M. Manchia, C. Chillotti et al.· International Journal of Neu...· 0 citations
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