Longitudinal transcriptomic profiling of paired early and metastatic EGFR-mutant lung adenocarcinomas reveals molecular programs associated with disease progression.
BACKGROUND The molecular mechanisms driving the progression of EGFR-mutated lung adenocarcinoma (LUAD) from localized to metastatic disease remain incompletely understood. We aimed to characterize transcriptomic alterations associated with disease progression by analyzing longitudinally paired tumor samples from patien...