BACKGROUND
As individuals with Down syndrome age, they face high risks of Alzheimer's disease and epilepsy. With symptomatic Alzheimer's disease, late-onset myoclonic epilepsy in Down syndrome (LOMEDS) often emerges. We aimed to examine how epilepsy develops in Down syndrome, its timing relative to Alzheimer's disease...
Lucía Maure-Blesa, M. Carmona-Iragui, I. Barroeta et al.· The Lancet· 1 citation
BACKGROUND
Down syndrome (DS) entails widespread age-related functional decline affecting multiple organ systems, including genetically determined early-onset Alzheimer disease (DSAD), resulting in an increased vulnerability to frailty early in life. We investigated the relationship between frailty, cognition and intel...
Georg S. Nuebling, Lena Marth, K. Sandkühler et al.· Journal of Intellectual Disa...· 0 citations
Background and Objectives Adults with Down syndrome (DS) have an increased risk of developing early Alzheimer disease. While our previous cross-sectional study investigated the blood proteome in the context of Alzheimer in DS, identifying CBLN4, CD14, C-X-C motif chemokine 17 (CXCL17), ectodysplasin A2 receptor (EDA2R)...
Olivia Wagemann, Georg S. Nuebling, K. Sandkühler et al.· Neurology· 0 citations
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