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A. Sun

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Open access Oct 2026

Histone lactylation-mediated metabolic remodeling in vascular smooth muscle cells aggravates aortic aneurysm and dissection via promoting lactate accumulation

Vascular smooth muscle cells (VSMCs) undergo phenotypic changes during the development of aortic aneurysm and dissection (AAD). Metabolism shifts from oxidative phosphorylation (OXPHOS) to glycolysis. Recent studies suggested glycolysis-associated histone lactylation was involved in the regulation of cardiovascul...

L. Liu, J. Ge, A. Sun · 0 citations

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