Accuracy of type 2 inflammatory biomarkers to diagnose asthma in adults and children: a meta-analysis of 30 studies with prospective validation in an adult primary care cohort.
BACKGROUND Asthma diagnosis is challenging, partly due to low yield of bronchodilator reversibility and limited access to bronchial provocation tests (BPTs). Fractional exhaled nitric oxide (FeNO) and blood eosinophil count (BEC) have been proposed as rule-in biomarkers. We aimed to evaluate the diagnostic accuracy of...