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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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A. Tabor

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Open access Sep 2026

Directed Oxidative Folding of Disulfide-Rich Peptides (DRPs) Using a Pseudoproline Unit: Ion Mobility-Mass Spectrometry (IM-MS) Reveals the Conformational Landscape of the DRP

Disulfide-rich peptides (DRPs) are attractive drug development scaffolds due to their exceptional stability and specificity. Regioselective disulfide bond formation is often achieved via orthogonal Cys protecting groups or strategic Pro placement. However, Cys protection strategies are labor-intensive and low-yielding,...

Declan T. Cook, Kish R. Adoni, Konstantinos Thalassinos et al. · 0 citations

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