Author

A. Taher

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Open access Sep 2026

Design, synthesis, structure-activity relationship and in-silico studies of novel pyrazolo[1,5-a]pyrimidine derivatives as selective COX-2 inhibitors with promising anti-inflammatory activity and safety profile.

A novel series of pyrazolo[1,5-a]pyrimidine derivatives was designed using ligand-based pharmacophore modeling, and their structures were confirmed by 1H/13C NMR and LC-MS, establishing 8a and 8i as potent, selective, and structurally stable lead candidates for preclinical COX-2 inhibitor development.

Alaa Omar Mohamed Helmy, A. Taher, Eman Z. El Razaz et al. · Bioorganic chemistry (Print) · 0 citations

Open access Sep 2026

Dual inhibitors of CDK2 and TRKA kinases: design, synthesis, antiproliferative activity and molecular modeling of novel pyrazolopyrimidine derivatives

Simultaneous inhibition of CDK2 and TRKA presents a promising therapeutic avenue for cancer treatment, capitalizing on the critical roles of CDK2 in cell cycle regulation and TRKA in tumor cell survival and progression. In continuation of our previous work on dual CDK2/TRKA inhibitors, two series of pyrazolo[1,5-a]pyri...

Mohamed H. Attia, Deena S. Lasheen, Nermin Samir et al. · RSC Advances · 0 citations

Review Open access Jul 2026

Unlocking new antimicrobial leads in the last decade: exploring quinolin-2-one based hybrids' synthesis, action, SAR, and challenges in tackling antimicrobial resistance.

Quinolin-2-one derivatives demonstrated considerable therapeutic promise as versatile antimicrobial scaffolds, but current studies revealed several limitations, including poor aqueous solubility, insufficient preclinical ADMET characterization, and limited in vivo validation.

M. A. Khattab, Sha-Hin I. Mai, A. Taher et al. · Future Medicinal Chemistry · 0 citations