The present retrospective multicenter study in Japan evaluated the role of venetoclax plus azacitidine (V/A) before first allogeneic hematopoietic stem cell transplantation (SCT) in 144 transplant-eligible acute myeloid leukemia (AML). Thirty-seven patients received V/A prior to SCT, mainly as salvage therapy for refra...
Hiroyuki Muranushi, J. Kanda, Tadakazu Kondo et al.· Clinical Hematology Internat...· 0 citations
Background Conventional antibody discovery approaches that do not account for enrichment-driven biases, such as epitope immunogenicity, PCR amplification bias, or protein expression efficiency, may result in under-representation of rare yet functionally relevant clones, necessitating labor-intensive in vitro screening...
Tomoki Iemura, T. Kitawaki, R. Maeda et al.· Journal for ImmunoTherapy of...· 0 citations
Replication stress (RS) represents a major vulnerability of cancer cells treated with nucleoside analogs and related antimetabolites; however, tumors frequently acquire tolerance mechanisms that permit survival despite persistent DNA lesions. This review examines molecular determinants of RS tolerance, focusing on huma...
It is demonstrated that SLF2 and SMC5 dysfunction drives premature HSC aging, bone marrow failure, and predisposition to MDS, revealing Atelis Syndrome as a previously unrecognized IBMFS.
Sho Shibata, K. Chonabayashi, Hirofumi Nakamura et al.· Leukemia· 1 citation
These findings suggest the safety and potential efficacy of allogeneic iPSC-PLTs in humans, and are reported the world’s first clinical evaluation of an allogeneic iPSC-PLT product.
Kazumasa Takao, Yoshihiro Kumagae, J. Kanda et al.· Stem Cells Translational Med...· 0 citations
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