Atsushi Toyoda

Identification of an atypical microRNA with sequence variation in the silkworm Bombyx mori

MicroRNAs (miRNAs) play essential roles in posttranscriptional regulation of gene expression. During miRNA biosynthesis, miRNA precursors are cleaved by Dicer at their loop structure to generate mature miRNAs. However, the functional consequences of sequence alterations in the loop region remain poorly understood. The...

Whole genome sequences and annotations of Japanese and French strains of Heterosigma akashiwo

Cohesin prevents local mixing of condensed euchromatic domains in living human cells

The human genome is folded into chromatin loops by the cohesin complex, forming functional chromatin domains that underlie transcription and DNA replication/repair. However, how cohesin organizes these domains in living cells, especially in active euchromatin, remains elusive. Here, to address this question, we combine...

RPL41 stabilizes ribosome dynamics and supports long-protein homeostasis in mammals

Cryo-electron microscopy reveals a conserved role for RPL41 in maintaining ribosome dynamics and translational fidelity, indicating that RPL41 supports ribosome function and long-protein homeostasis in mammals.