A. Trumpp

Abstract IA009: Profiling and targeting pancreatic cancer innervating neurons

The peripheral nervous system (PNS) orchestrates organ function in health and disease. Many cancers, including pancreatic ductal adenocarcinoma (PDAC), are infiltrated by PNS neurons that contribute to the complexity of the tumor microenvironment (TME). However, the cell bodies of these neurons reside in distant PNS...

Trace-n-Seq combines retrograde fluorescent tracing with sorting and single-cell sequencing of innervating peripheral neurons.

CD3-engaging bispecific antibodies convert human regulatory T cells into cytotoxic effectors

Latent effector T cells mediate immunotherapy responses in the bone marrow microenvironment.

TFiT (tumor-reactive features in T cells), a transcriptional classifier that identifies tumor-reactive T cells and stratifies immunotherapy, but not chemotherapy, response across independent MM and AML cohorts, supporting its specificity for T cell-mediated tumor control.