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Author

A. Tsuchida

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Open access 2026

Comprehensive diffusion MRI analysis reveals key microstructural alterations underlying white matter hyperintensities

Cerebral small vessel disease (CSVD) is a prevalent age-related condition and a major contributor to cognitive decline, dementia, and stroke. Its most common MRI marker, white matter hyperintensities (WMH), reflects heterogeneous microstructural alterations, including demyelination, inflammation, and axonal loss. Mon...

Stanislas Thoumyre, A. Tsuchida, Arnaud Boré et al. · 0 citations
Open access Sep 2026

Pathway-specific polygenic risk scores reveal underlying mechanisms of cerebral small vessel disease

A validated WMH global-PRS is generated showing robust association with cSVD clinical complications and introduce a multi-cohort WMH ps-PRS framework that reveals candidate biological pathways with candidate biological associations across the lifespan and clinical outcomes.

T. D'Aoust, A. Tsuchida, C. Dufouil et al. · 0 citations

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