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Author

A. Tutt

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Review Open access Oct 2026

Meiotic recombination proteins in cancer.

Although mitotic cells normally suppress the expression of proteins involved in meiosis, a series of meiotic recombination proteins are commonly expressed in cancers, outside of their normal context. Here we review mechanistic and genomic evidence linking meiotic recombination proteins to cancer, focussing on HORMAD1,...

V. Amodeo, S. Pettitt, A. Tutt et al. · 0 citations
Open access Sep 2026

PUM3 is an essential suppressor of replication stress in homologous recombination deficient breast cancer

Most Triple Negative Breast Cancers (TNBCs) are p53 mutant high-grade invasive ductal carcinomas with a basal-like transcriptional programme. A large proportion of TNBCs also have mutation signatures indicating defective homologous recombination (HR) DNA repair. While HR deficiency is mutagenic and oncogenic, it can al...

V. Amodeo, D. Weekes, Nicolae Balan et al. · 0 citations

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