Perspectives of Natural Products and Sialic Acid Mimetics as Modulators of Human Sialidases NEU1–3 in Atherosclerosis
This narrative review summarizes current data on the role of desialylation of low-density lipoproteins (LDL) as a key initiating mechanism of atherogenesis that precedes oxidative modification. The structural and functional significance of sialic acid in apolipoprotein B-100 is considered, and the enzymes of the sialid...