Review
Open access
Aug 2026
Whole genome sequencing to elucidate novel genetic modifiers of FVIII clearance.
Despite significant insights into factor VIII (FVIII) biosynthesis, the mechanisms involved in FVIII clearance remain poorly defined. To investigate genetic modifiers of FVIII clearance, we studied 106 SNPs across 43 different loci previously reported to influence plasma FVIII and/or von Willebrand (VWF) levels and rev...
A. Hulshof, Lilian Antunes Heck, F. Atiq et al.
· Blood · 0 citations