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Open access Oct 2026

Risk factors and outcome of children and young adults with initially unresected nonrhabdomyosarcoma soft tissue sarcoma: An analysis from the International Soft Tissue Sarcoma Consortium

The role of neoadjuvant therapy in children, adolescents, and young adults (CAYA) with initially unresectable nonrhabdomyosarcoma soft tissue sarcoma (NRSTS) remains controversial, with recommendations varying by cooperative group. The International Soft Tissue Sarcoma Consortium (INSTRuCT) is a collaboration among Nor...

A. Weiss, James R. Anderson, Sonja D. Chen et al. · 0 citations
Sep 2026

Abstract A003: Safety and efficacy of autologous tumor infiltrating lymphocyte therapy in pediatric and adolescent patients with immune checkpoint inhibitor-refractory metastatic melanoma: Results from a phase I clinical trial

Lifileucel is an autologous tumor infiltrating lymphocyte (TIL) therapy approved for adults with unresectable or metastatic melanoma previously treated with a PD-1 inhibitor and/or targeted therapy. Pediatric data have been lacking. We report preliminary safety, feasibility, and efficacy results from the melanoma...

S. Sait, J. Honeyman, S. Stapleton et al. · 0 citations

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