Author

A. Wesselius

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#data science Review Open access Oct 2026

The impact of intratumor heterogeneity on outcome and resistance to therapy in primary breast cancer: a systematic review

Intratumor heterogeneity (ITH), the coexistence of diverse subclones within a single tumor, may pose a major challenge to effective chemotherapy in breast cancer. This cellular diversity contributes to treatment failure, residual disease, and early relapse by enabling tumor adaptation and therapeutic resistance. Althou...

Aria Dianati, Andre Dekker, A. Wesselius et al. · Medical Oncology · 0 citations

Open access Aug 2026

Mediterranean diet adherence, healthy sleep, and lung cancer risk: a prospective study of 192,034 UK Biobank participants

Diet and sleep have each been associated with cancer risk, but their joint association with lung cancer risk remains unclear. We investigated the association between a joint Mediterranean diet-sleep pattern and lung cancer risk in the UK Biobank. We also evaluated whether siesta modified the association between Mediter...

Yi-Ming Chen, En-Yu Tong, Xiao-Man Jin et al. · European Journal of Nutritio... · 0 citations

Aug 2026

Modeling the complex smoking exposure history in assessment of pan-cancer risk.

The findings show that smoking pattern and cessation history meaningfully influence pan-cancer risk beyond cumulative exposure, supporting the incorporation of detailed smoking histories-intensity, duration, and cessation-into risk stratification, screening eligibility, and prevention strategies.

Wei Liu, Ya-Ting Chen, B. Tao et al. · MedScience · 0 citations