Understanding how genetic variation shapes gene regulation at single-cell resolution is crucial for elucidating complex disease mechanisms1, but has been limited by the lack of large-scale single-cell multi-omics data2-4. Here we present single-cell assay for transposase-accessible chromatin with sequencing of 3.5 mill...
A. Xue, Jia-Nan Fan, Oscar A. Dong et al.· Nature· 3 citations
Understanding the genetic basis of gene expression can shed light on the regulatory mechanisms underlying complex traits and diseases1,2. Single-cell-resolved measures of RNA levels and single-cell expression quantitative trait loci have revealed genetic regulation that drives cell states and types across diverse tissu...
Anna S. E. Cuomo, E. Spenceley, H. Tanudisastro et al.· Nature· 3 citations
Gene expression levels can vary substantially across cells, even in a seemingly homogeneous cell population. Identifying the relationships between genetic variation and gene expression is critical for understanding the mechanisms of genome regulation. However, the genetic control of gene expression variability among th...
A. Xue, S. Yazar, José Alquicira-Hernández et al.· bioRxiv· 1 citation
