Biofilm disruption vs. rapid resistance: Evaluating the role of Calliphora vicina defensin in Staphylococcus aureus clearance.
Defensins are evolutionarily conserved antimicrobial peptides (AMPs) considered a cornerstone of innate immunity. However, the rapid emergence of resistance in pathogens like Staphylococcus aureus challenges our understanding of defensin efficacy in vivo. We used the blowfly Calliphora vicina-an insect adapted to patho...