Review
Open access
Sep 2026
Structural biology of the TRPM4 channel: architecture, modulation, and therapeutic opportunities
TRPM4 is a Ca2+-activated, monovalent-selective cation channel that conducts Na+ and K+ while remaining essentially impermeable to Ca2+. By translating cytosolic Ca2+ elevations into membrane depolarization rather than additional Ca2+ influx, TRPM4 operates as an electrical signal converter that tunes excitability, sec...
I. Araya-Durán, Marena Rein, Daniella Delgado et al.
· Frontiers in Pharmacology · 0 citations