A. Yisimayi

Perforin triggers iron-induced mitochondrial damage to drive ferroptosis and anti-tumor immunity.

Cytotoxic CD8+ T cells and natural killer cells are critical effectors of anti-tumor immunity. Cytotoxic lymphocytes eliminate tumor cells by releasing perforin (Prf1), a pore-forming protein that enables granzymes (Gzms) to enter target cells and trigger both caspase-dependent and -independent cell death. Here, we unc...