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Wearable-derived variability metrics capture key residual inter-episode disturbances missed by mean-level measures, supporting their further evaluation as research phenotypes in prospective mood-state studies.
Introduction: Cognitive impairment and disturbed rest-activity patterns often persist between episodes of major depressive disorder (MDD) and bipolar disorder (BD). Whether these deficits are disorder-specific or transdiagnostic remains unclear, as does the existence of a link between rest-activity phenotypes and cogni...
Operating directly on routine preoperative evaluations without requiring additional testing, this computational framework disentangles pathological burden from network reserve, providing scalable, biologically interpretable biomarkers to guide personalized risk counselling and network-informed surgical planning.
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