Hexachlorobutadiene exposure promotes hepatocellular carcinoma progression via CD8+ T dysfunction and VDR-mediated PI3K/AKT activation: An integrated multi-omics and experimental study.
Hexachlorobutadiene (HCBD), a persistent organic pollutant listed under the Stockholm Convention, has raised increasing concern due to its potential health risks; however, its role in hepatocellular carcinoma (HCC) progression remains unclear. In this study, we systematically investigated the toxicological effects and...