Genome-Guided Discovery of Floridanemastatin, a Statine-Containing Polyketide-Peptide from the Cyanobacterium Floridanema evergladense.
We report the genome-guided discovery, isolation, and characterization of floridanemastatin (1), a previously undescribed statine-containing polyketide-peptide from Floridanema evergladense BLCC-F167. Examination of the biosynthetic gene clusters in the F.evergladense genome revealed a hybrid PKS-NRPS biosynthetic gene...