Author

Aakash Chandramouli

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Open access Oct 2026

A voltage-gated porin PPE1 regulates secretion and drug resistance in Mycobacterium tuberculosis.

Drug resistance in Mycobacterium tuberculosis (Mtb) remains a formidable clinical hurdle, compounded by the fact that the pathways by which antibiotics penetrate its multilayered cell envelope remain incompletely mapped. We identify PPE1 as a voltage-gated outer-membrane porin that mediates the secretion of kupyaphores...

Mohit Yadav, Neilah Firzan C. A, D. Mandal et al. · Proceedings of the National... · 0 citations

Open access Aug 2026

Glial ceramide orchestrates lipid homeostasis and age-dependent motor function.

Glial cells have emerged as equal partners to neurons in the development and maintenance of the nervous system. In this study, we examine the consequences of modulating glial ceramide metabolism on adult motor function. Glial reduction of ER-localised ceramide synthesis, as exemplified by knockdown (KD) of schlank or i...

Lovleen Garg, Karthik H, Aakash Chandramouli et al. · Disease Models & Mechanisms · 0 citations

Open access Sep 2026

Orthogonal Chemical Proteomic Strategies Reveal the Cholesteryl Ester Interactome in Mammalian Cells

Cholesteryl esters (CEs) are widely regarded as inert storage forms of cholesterol, yet their potential to directly engage cellular proteins remains largely unexplored. Here, we establish an integrated chemical proteomic platform to systematically define CE–protein interactions in mammalian cells. We developed and comp...

Aakash Chandramouli, Kavita Sharma, Adithya Kallattu et al. · bioRxiv · 0 citations