Aaron D. Milstein

GIRK Channel Loss of Function Increases Dendritic Excitability in a Mouse Model of GNB1 Encephalopathy

It is shown that a pathogenic variant of the G protein subunit Gβ1 impairs activation of neuronal G-protein-coupled inwardly rectifying potassium (GIRK) channels by inhibitory synaptic GABAB receptors, which leads to increased dendritic excitability and longer duration dendritic calcium spikes in mouse hippocampal neur...