Aaron P. Mitchell

A negative role for master regulator Bcr1 in Candida albicans hypha-associated gene expression

Filamentation, a central virulence trait of the fungal pathogen Candida albicans, is required for host cell damage, tissue invasion, and biofilm formation. The transcription factor Bcr1 was first found to be required for biofilm formation but not filamentation. Subsequent studies revealed a negative role for Bcr1 in fi...