N-(3-Trifluoromethylphenyl)sulfonyl-indole-3-carbaldehyde thiosemicarbazones induce apoptosis and modulate p53-associated signaling in prostate cancer: integrated experimental and computational studies.
Prostate cancer continues to be an important therapeutic challenge that demands the development of new apoptosis-inducing agents. In the present study, a series of N-(3-trifluoromethylphenyl)sulfonyl-indole-3-carbaldehyde thiosemicarbazone derivatives (5a-s) was synthesized and evaluated for their biological activity a...