Author

Abedalrhman Alkhateeb

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Open access Sep 2026

External Evaluation of Multi-Omics Prognostic Models Across TCGA-BRCA and METABRIC: Transportability, Stability, and Incremental Performance

Cross-cohort evaluation of multi-omics prognostic models can fail because molecular features are not assayable, fitted models do not transport, feature selection is unstable, or molecular data add little beyond clinical predictors. We used a dual-track evaluation design with TCGA-BRCA as the source cohort and METABRIC...

E. Krikun, Abedalrhman Alkhateeb · bioRxiv · 0 citations

Review Open access Sep 2026

Evidence-Grounded Clinical Pharmacogenomics Decision Support: Integrating Fine-Tuned Large Language Models with Hybrid Retrieval-Augmented Generation

A data-driven clinical decision support framework that combines large language models (LLMs) with hybrid retrieval-augmented generation (RAG) to improve answers to PGx queries is proposed, showing that combining retrieval methods with parameter-efficient fine-tuning enhances LLM reliability in clinical settings.

Protiva Arafin, Md. Moniruzzaman, Abedalrhman Alkhateeb · Applied Sciences · 0 citations

Jul 2026

A Markov Blanket-based framework for dependency-aware feature selection in multimodal breast cancer data

A multimodal Markov Blanket (MB)-based feature selection framework that performs local structure learning across seven data modalities and introduces a composite dependency-ranking fallback when sparse neighborhoods lead to data starvation is developed.

Elena Krikun, Abedalrhman Alkhateeb · Network Modeling Analysis in... · 0 citations