Sep 2026
A 2-in-1 Strategy for the Discovery of Compact HDAC8 Protac Degraders
A “2-in-1” PROTAC design strategy for developing more compact HDAC8 degraders by integrating the CRBN-recruiting ligand into the capping group of an HDAC8 warhead, thereby enabling a single structural motif to engage both HDAC8 and CRBN.
Yi Liu, Nikee Awasthee, Yufeng Xiao et al.
· Journal of Medicinal Chemist... · 0 citations