Abhishek Kumar Singh

Extending the Lifespan of Human Mesenchymal Stromal Cells: Approaches to Immortalization and Clinical Prospects.

Mesenchymal stromal cells (MSCs) have a limited proliferative lifespan associated with replicative senescence, although the extent and onset of replicative senescence may vary among MSC sources. The immortalization of MSCs is being investigated as a strategy to extend proliferative capacity and facilitate scale-up. Mor...