Abhishek Lakhera

Mechanistic insights into Mfd inhibition by pharmacophore-guided ligands using molecular and steered molecular dynamics simulations.

Antimicrobial resistance remains difficult to control because many bacteria rely on DNA repair pathways that help them survive antibiotic stress. One of the key players in this response is the Mutation Frequency Decline protein (Mfd), a transcription repair coupling factor that supports mutagenesis and persistence. Tar...