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Author

Abigail H. Evered

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Open access Sep 2026

The anti-leukemia drug ponatinib attenuates NLRP3 inflammasome activation in macrophages

The NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is an established driver of inflammation in diseases such as diabetes, Alzheimer's disease, and gout. Previously, we screened 875 FDA-approved drugs for NLRP3 inhibitors and identified ponatinib as one of the five candidates that reduced NLRP3...

Abigail H. Evered, Daniel C. Shippy, Jaidynne N. Lash et al. · 0 citations
Open access Jul 2026

Equol inhibits NLRP3 inflammasome activation in macrophages 2257578

The intestinal microbiome produces a vast number of metabolites. Many of these metabolites have immunomodulatory properties including the ability to inhibit the NOD, LRR, and pyrin-domain containing 3 (NLRP3) inflammasome, an established driver of inflammation in many diseases including gout, psoriasis, and Alzhe...

Abigail H. Evered, Daniel C. Shippy, Tyler K. Ulland · 0 citations

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