Abigail H. Kendal

DNA polymerase I and DnaE mediate RNA-templated DNA synthesis over embedded ribonucleotides

Abstract It is established that during normal growth and under stress, ribonucleotides become nested in genomic DNA. Given the high frequency with which RNA is found in DNA, it is unknown which bacterial DNA polymerases are responsible for catalyzing RNA-dependent DNA synthesis. In this work, we establish bacterial DNA...