Abigail Strege

Absence of a spindle position checkpoint in the fungal pathogen Cryptococcus neoformans

To maintain genome stability, it is crucial that cells do not initiate cytokinesis until chromosomes have been properly segregated. In the model budding yeast Saccharomyces cerevisiae, a surveillance mechanism called the Spindle Position Checkpoint (SPoC) ensures this coordination by regulating the Mitotic Exit Network...