Cobalt-catalyzed construction of spiro scaffolds bearing central and axial chirality via enantioselective (4+1) C–H spiroannulation
The construction of structurally complex, stereochemically rich spirocyclic frameworks remains a formidable challenge in organic synthesis, particularly when multiple stereoelements installed with precision in a single operation. Herein, we disclose a cobalt/Salicyloxazoline (Salox) catalyzed (4 + 1) spiroannulation...