Targeting the AMPK/SIRT1-NLRP3 Inflammasome Axis: Simvastatin, Ezetimibe, and Their Combination Attenuate 3-Nitropropionic Acid-Induced Striatal Neurodegeneration in Rats.
Striatal neurodegeneration, a prominent pathological feature of several neurological disorders, is associated with progressive behavioral decline alongside cognitive and motor dysfunction, reflecting the critical regulatory role of the striatum in coordinating multiple aspects of brain function. Neuroinflammation, part...