Open access
Sep 2026
Loss of killifish cGAS attenuates age-related signatures but does not affect organismal life span.
The cGAS/STING pathway is a central innate immune signaling pathway responsive to cytosolic DNA. Chronic activation of this pathway promotes numerous age-related pathologies, but its impact on lifespan remains unknown. Here we engineer a cGAS knockout (KO) in the turquoise killifish Nothobranchius furzeri to assess eff...
Eugen Ballhysa, Roberto Ripa, Nadine Hochhard et al.
· EMBO Reports · 0 citations