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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Adam Lesner

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Review Aug 2026

Targeting peptidylarginine deiminases 2 and 4 in diabetic kidney disease: mechanistic rationale and preclinical evidence.

Many patients with diabetic kidney disease (DKD) continue to progress despite guideline-directed quadruple nephroprotective therapy, driven in part by sterile inflammation that current treatment does not target. Peptidylarginine deiminases 2 and 4 (PAD2/4) are calcium-dependent enzymes that convert peptidyl-arginine to...

Wiktoria Mallek, Aleksandra Wróblewska-Schmude, Adam Lesner et al. · 0 citations

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