Open access
Aug 2026
Synthesis, modelling, biological activity of new thiophene hybridized with pyrazole, and/or pyridine analogues as potential DNA gyrase and topoisomerase IV inhibitors
The study displayed the synthesis of two series of thiophene-pyrazole hybrids, 7a-c and thiophene-pyridine hybrids 9a-c, via reacting arylhydrazone with halogenated reagents and nucleophilic addition of cyanoacetamide to the arylidene-malononitrile, respectively, and the chemical structure was elucidated using relia...
Abdulrahman S. Alharbi, Shadiah Albalawi, Asmaa L Alanzy et al.
· Arabian Journal of Chemistry · 0 citations