Non-genetic intratumor heterogeneity underlies therapeutic failure in cancer, yet how resistant tumor states are encoded in patients remains unclear. In this study, we show that chemoresistant evolution in high-grade serous ovarian cancer (HGSOC) is prefigured by epigenetically primed tumor cell states present before t...
Y. Landais, J. Bertorello, M. Puerto et al.· Cancer Discovery· 0 citations
Following infection, hematopoietic stem and progenitor cells (HSPCs) support immunity by increasing the rate of innate immune cell production but the metabolic cues that guide this process are unknown. To address this question, we combined in situ RNA barcoding and metabolomics approaches to perform metabolic state-fat...
J. Cosgrove, A. Donada, A. Lyne et al.· bioRxiv· 0 citations
This approach uncovers epigenomic priming of basal cells in the mammary gland and captures the dynamics of basal-to-luminal transdifferentiation, suggesting that epigenomic and transcriptional remodeling do not occur in complete synchrony during cell-fate conversion.
Anna Schwager, Eve Moutaux, Adeline Durand et al.· Nature Biotechnology· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.