Impact of Amphiphilic Balance on Nano-Bio Interactions of Peptide Amphiphile Nanostructures.
It is shown that, while PAs with hydrophilic peptide backbones and payloads mostly disassembled in blood plasma, increasing overall hydrophobicity improved their stability and it is reported that disassembled PAs can bind to blood biomolecules and binding shifted from albumin to lipoproteins with increasing hydrophobic...