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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

Aditi Gnanasekar

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Open access Sep 2026

Inverted logic of ecDNA localization converts nuclear periphery into oncogenic transcription hubs in cancer

It is shown that ecDNAs, in contrast to chromosomal DNA, preferentially localize to the nuclear periphery yet resist peripheral gene silencing, and single-molecule multi-omic sequencing and imaging-based CRISPR screening demonstrate enhanced ecDNA hub formation, H3K27ac and H3K9me3 bivalency, late DNA replication, long...

Yan-Bo Wang, Xiao-Wei Yan, Natasha E. Weiser et al. · 0 citations

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