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Adolfo García-Sastre

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Open access Aug 2026

A One-Shot Multivalent Live-Attenuated Candidate Influenza Vaccine against Divergent Zoonotic H5N1 Clades

The development and implementation of this multivalent LAIV as a broadly protective pan-H5N1 LAIV for pandemic preparedness are supported and the feasibility of developing and implementing this multivalent LAIV as a broad protective pan-H5N1 LAIV against divergent H5N1 viruses for human use is demonstrated.

Ahmed M. Elsayed, Ramya S. Barre, Arash Rahmani et al. · 0 citations
Open access Aug 2026

Mutations in SARS-CoV-2 Nsp1 are critical determinants of viral pathogenicity in mice

The reduced pathogenicity of rSARS-CoV-2 Nsp1 mutants highlights the potential for targeting Nsp1 for rational design of viral inhibitors and development of live-attenuated vaccine strategies as effective prophylactic and therapeutic treatments to combat SARS-CoV-2 and possibly other CoV infections.

Nathaniel Jackson, Fu-Chun Zhou, Anastasija Cupic et al. · 0 citations
Open access Aug 2026

Enhanced Pathogenicity and Contact Transmissibility of Human-origin Avian Influenza H5N1 Clade 2.3.4.4b Genotype B3.13 Compared to D1.1 in Ferrets

Using the ferret model of influenza infection and transmission, it is demonstrated that the currently circulating B3.3.13 is already well adapted for mammalian infection and transmission whereas D1.1 rapidly acquires mammalian-adaptive mutations after a single infection and/or transmission event, highlighting its evolu...

Ahmed M. Elsayed, Ramya S. Barre, Mahmoud Bayoumi et al. · 0 citations

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